Table 2. Interrogation of known loci in EA in AA for the trait eGFRcrea; best SNP at each locus is shown below; SNP ID in bold from Kottgen et al, Nature Genetics 2009, and Nature Genetics 2010.

SNP ID in EA	Chr	Genes Within 60 kb	Coded Allele Frequency (allele)	Beta coefficient in EA relative to coded allele	Coded allele frequency for the lead SNPs in EA in AA (allele)	Beta coefficient in AA for the lead SNP in EA	p-value in AA for lead SNP in EA
rs17319721	4	SHROOM3	0.43 (A)	−0.013	0.22 (A)	−0.004	0.44
rs10109414	8	STC1	0.42 (T)	−0.008	0.34 (T)	−0.005	0.30
rs4293393*	16	UMOD	0.82 (A)	−0.016	0.81 (A)	−0.013	0.01
rs267734	1	ANXA9	0.8 (T)	−0.010	0.96 (T)	−0.016	0.13
rs1260326	2	GCKR	0.41 (T)	0.009	0.16 (T)	0.007	0.24
rs13538	2	ALMS1	0.77 (A)	−0.009	0.48 (A)	−0.003	0.57
rs347685	3	TFDP2	0.72 (A)	−0.009	0.75 (A)	−0.007	0.13
rs11959928	5	DAB2	0.44 (A)	−0.009	0.30 (A)	−0.002	0.75
rs6420094	5	SLC34A1	0.66 (A)	0.011	0.83 (A)	−0.002	0.83
rs881858	6	VEGFA	0.72 (A)	−0.011	0.36 (A)	−0.003	0.50
rs10224210	7	PRKAG2	0.73 (T)	0.010	0.92 (T)	0.019	0.06
rs4744712	9	PIP5K1B	0.39 (A)	−0.008	0.42 (A)	−0.015	0.0003
rs653178	12	ATXN2	0.51 (T)	0.003	0.92 (T)	0.001	0.87
rs626277	13	DACH1	0.60 (A)	−0.009	0.34 (A)	−0.003	0.50
rs1394125	15	UBE2Q2	0.35 (A)	−0.009	0.35 (A)	−0.007	0.15
rs12460876	19	SLC7A9	0.61 (T)	−0.008	0.72 (T)	−0.010	0.03
rs10794720	10	WDR37	0.08 (T)	−0.014	0.21 (T)	−0.007	0.18
rs491567	15	WDR72	0.78 (A)	−0.009	0.45 (A)	−0.001	0.87
rs2453533	15	SPATA5L1;GATM	0.38 (A)	−0.013	0.84 (A)	−0.008	0.18
rs7422339	2	CPS1	0.32 (A)	−0.009	0.32 (A)	−0.005	0.38
rs2279463**	6	SLC22A2	0.88 (A)	0.013	N/A	N/A	N/A
rs6465825	7	TMEM60	0.61 (T)	0.008	0.51 (T)	0.000	0.92
rs10774021	12	SLC6A13	0.64 (T)	−0.008	0.50 (T)	−0.005	0.23
rs9895661	17	BCAS3	0.81 (T)	0.011	0.53 (T)	0.008	0.05

* Lead SNP rs12917707 in EA not present in AA dataset; therefore used rs4293393, which is in perfect LD in EA (r2 = 1.0).

** rs2279463 not present in AA dataset.