Table 3. Interrogation of known loci in EA in AA for the trait eGFRcrea; best SNP at each locus is shown below; SNP ID in bold from Kottgen et al, Nature Genetics 2009, and Nature Genetics 2010.
| SNP ID in EA | Chr | Best SNP ID in AA in the Region | Coded Allele Frequency in AA (allele) | Beta coefficient in AA for best SNP | P-value in AA | Number of independent (typed) SNPs interrogated in CARe AA | Bonferroni p-value threshhold (0.05/P) | Replication beta coefficient | Replication p-value | Stage 1+Stage 2 beta | Stage 1+Stage 2 p-value |
| rs17319721 | 4 | rs4371638 | 0.19 (T) | −0.020 | 0.003 | 28 | 0.002 | −0.002 | 0.42 | −0.015 | 8.8E-03 |
| rs10109414 | 8 | rs192841 | 0.79 (A) | −0.016 | 0.007 | 29 | 0.002 | 0.012 | 0.91 | −0.008 | 1.3E-01 |
| rs4293393 | 16 | rs4293393 | 0.81 (A) | −0.013 | 0.014 | 14 | 0.004 | −0.017 | 0.02 | −0.014 | 1.5E-03 |
| rs267734 | 1 | rs3738479 | 0.39 (A) | 0.013 | 0.005 | 19 | 0.003 | 0.012 | 0.04 | 0.013 | 9.0E-04 |
| rs1260326 | 2 | rs13022873 | 0.81 (A) | 0.013 | 0.017 | 17 | 0.003 | 0.007 | 0.21 | 0.011 | 1.3E-02 |
| rs13538 | 2 | rs7600291 | 0.58 (C) | 0.011 | 0.011 | 19 | 0.003 | −0.011 | 0.93 | 0.005 | 1.6E-01 |
| rs347685 | 3 | rs6781340 | 0.41 (T) | −0.014 | 0.002 | 21 | 0.002 | −0.014 | 0.03 | −0.014 | 2.1E-04 |
| rs11959928 | 5 | rs3822460 | 0.83 (T) | −0.013 | 0.020 | 11 | 0.005 | −0.010 | 0.13 | −0.012 | 1.0E-02 |
| rs6420094 | 5 | rs10463065 | 0.95 (C) | 0.032 | 0.004 | 20 | 0.003 | −0.001 | 0.52 | 0.023 | 1.6E-02 |
| rs881858 | 6 | rs1750571 | 0.07 (A) | 0.023 | 0.005 | 31 | 0.002 | 0.027 | 0.02 | 0.024 | 5.0E-04 |
| rs10224210 | 7 | rs6464167 | 0.42 (A) | 0.015 | 0.021 | 20 | 0.003 | 0.004 | 0.33 | 0.010 | 3.5E-02 |
| rs4744712 | 9 | rs1556751 | 0.59 (A) | 0.016 | 0.0002 | 65 | 0.001 | 0.006 | 0.19 | 0.013 | 2.6E-04 |
| rs653178 | 12 | rs12302645 | 0.94 (A) | −0.018 | 0.050 | 10 | 0.005 | −0.014 | 0.16 | −0.017 | 3.0E-02 |
| rs626277 | 13 | rs9318029 | 0.13(T) | 0.016 | 0.046 | 7 | 0.007 | 0.002 | 0.42 | 0.011 | 8.5E-02 |
| rs1394125 | 15 | rs2454472 | 0.84 (A) | −0.020 | 0.0009 | 28 | 0.002 | −0.007 | 0.25 | −0.016 | 1.4E-03 |
| rs12460876 | 19 | rs3795058 | 0.43 (C) | −0.012 | 0.004 | 30 | 0.002 | 0.009 | 0.88 | −0.007 | 6.7E-02 |
| rs10794720 | 10 | rs2805575 | 0.20 (C) | 0.013 | 0.01 | 45 | 0.001 | −0.016 | 0.97 | 0.005 | 2.3E-01 |
| rs491567 | 15 | rs16966247 | 0.17 (C) | −0.022 | 0.0002 | 35 | 0.001 | −0.004 | 0.31 | −0.017 | 6.0E-04 |
| rs2453533 | 15 | rs1153859 | 0.52 (T) | −0.014 | 0.001 | 14 | 0.004 | −0.012 | 0.04 | −0.013 | 2.2E-04 |
| rs7422339 | 2 | rs957749 | 0.79 (A) | −0.011 | 0.04 | 13 | 0.004 | 0.007 | 0.82 | −0.006 | 2.0E-01 |
| rs2279463 | 6 | rs3798156 | 0.12 (T) | −0.027 | 7.8E-05 | 22 | 0.002 | −0.032 | 0.003 | −0.028 | 1.2E-06 |
| rs6465825 | 7 | rs6973213 | 0.20 (A) | −0.019 | 2.79E-04 | 25 | 0.002 | −0.008 | 0.19 | −0.017 | 2.75E-04 |
| rs10774021 | 12 | rs485514 | 0.91 (T) | 0.019 | 0.03 | 20 | 0.003 | 0.013 | 0.17 | 0.017 | 1.6E-02 |
| rs9895661 | 17 | rs11650989 | 0.22 (A) | 0.016 | 0.002 | 20 | 0.003 | 0.013 | 0.06 | 0.016 | 5.8E-04 |