Table 1. Initial, replication, and combined results for number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation scores averaged over multiple time points.

SNP (effect/other allele)	rs12424086 C/T					rs4491709 T/C					rs2281845 T/C					rs7924176 G/A
Study group	N	C freq.	Effect	SE	P-value	N	T freq.	Effect	SE	P-value	N	T freq.	Effect	SE	P-value	N	G freq.	Effect	SE	P-value
Initial stage
DNBC I GWAS	5099	0.177	−0.118	0.020	1.11E-08	5088	0.707	−0.109	0.017	6.51E-10	5097	0.381	−0.105	0.016	1.31E-10	5100	0.426	−0.094	0.016	6.58E-09
Replication stage
DNBC II	2162	0.166	−0.079	0.033	0.016	2171	0.717	−0.087	0.026	9.70E-04	2172	0.382	−0.099	0.025	5.43E-05	2172	0.420	−0.119	0.024	5.18E-07
DK Roskilde	671	0.186	−0.169	0.056	2.55E-03	690	0.698	−0.105	0.045	0.019	691	0.400	−0.165	0.042	1.09E-04	687	0.424	−0.089	0.043	0.040
USA	668	0.202	−0.130	0.067	0.051	669	0.732	−0.106	0.060	0.078	669	0.392	0.065	0.056	0.242	668	0.449	−0.160	0.051	1.80E-03
DK Glostrup	161	0.199	−0.020	0.094	0.833	161	0.730	−0.058	0.086	0.502	164	0.396	−0.175	0.069	0.012	163	0.439	−0.133	0.074	0.072
Replication combined	3662	0.177	−0.100	0.025	6.29E-05	3691	0.715	−0.091	0.021	9.09E-06	3696	0.388	−0.099	0.019	2.06E-07	3690	0.426	−0.120	0.019	1.25E-10
All combined	8761	0.177	−0.111	0.016	2.30E-12	8779	0.711	−0.102	0.013	2.16E-14	8793	0.384	−0.103	0.012	8.03E-17	8790	0.426	−0.105	0.012	5.64E-18
Heterogeneity P-value					0.528					0.947					0.015					0.678

Effect is given as the change in mean standard deviation score, so all effect alleles result in lower numbers of permanent teeth erupted. Alleles refer to the forward strand.