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. 2011 Sep 8;6(9):e23877. doi: 10.1371/journal.pone.0023877

Figure 4. Inhibition of in vitro capsid assembly by peptides H2, H3, H4 and H8.

Figure 4

(A) Crystallographic structural model of the CA hexamer [64]. Each CA monomer is shown in a different color. (B) Closeup of the arrangement of two neighboring CA monomers (labelled 1 and 2) in the CA hexamer depicted in panel (A). The orientation has been modified to show the CTD-NTD and NTD-NTD interfaces more clearly. Helices 2 in blue, 3 in red, 4 in orange and 8 in yellow are highlighted, and labelled H2, H3, H4 and H8, respectively. The sequences of the corresponding peptides are indicated. (C) Reaction kinetics of CA polymerization using the conditions described in the legend for Fig. 3. The traces are colored as follows: no peptide added (black); peptide H2 (blue); peptide H3 (red); peptide H4 (brown), all at a peptide∶inhibitor molar ratio of 10; peptide H8 at a peptide∶CA ratio of 5 (yellow); peptide H8 at a peptide∶CA molar ratio of 10 (orange).