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. 2011 Sep 8;6(9):e24082. doi: 10.1371/journal.pone.0024082

Table 1. GRIM-1 expression levels in normal and tumor specimens analyzed by immunohistochemistry.

Level@ Normal Tumor Loss (%)
+ ++ +++ ++++ +++++ Total + ++ +++ ++++ +++++ Total
Prostate 4 5 7 14 8 38 21 17 8 46
Prostate (paired) 3 3 4 8 6 24 7 11 6 24 75

@Expression level graded on an arbitrary scale (%) using signal ratio of GRIM-1 to DAPI.

+ (0–20) – Severe loss, ++ (21–40) – Significant loss, +++ (41–60) – Moderate loss, ++++ (61–80) – Slight loss, +++++ (81–100) – No loss.