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. 2011 Sep 8;6(9):e24168. doi: 10.1371/journal.pone.0024168

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Du et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–D) Uniform expression of Cul1 protein (B) in a wing disc expressing the ap-Gal4 driver. UAS-mCD8-gfp expression (C) reflects the ap-Gal4 activity in the dorsal (d) compartment (marked by the box bracket). (E–P) Regulation of Cul1 protein stability by CG13343. Knockdown of CG13343 expression by RNAi in the dorsal compartment of the wind disc resulted in significant accumulation of CiFL (E) and Cul1 (F). Analysis of CG13343 RNAi-overexpressing clones (positively marked by mCD8-GFP in K) in the anterior compartment (arrowheads) confirmed that the stability of CiFL (I) and Cul1 (J) was cell-autonomously regulated by CG13343. Similarly, stabilized CiFL (M, arrowheads) and Cul1 (N, arrowheads and arrow) were observed in CG13343^SH2028 loss-of-function somatic clones (negatively marked by nGFP in O) in the wing disc.