Figure 4. Learned Enhancement of Control over BOLD fMRI Activation and Mood Induction.

A significant training effect was observed for the left amygdala for the subjects in the experimental group. The control of BOLD fMRI activation in the left amygdala ROI monotonically increased over training runs and persisted during the Transfer run. Each bar represents mean percent signal change in the BOLD signal (± s.e.m.) averaged across Happy Memories conditions during a given run (see text for details) for each ROI (left amygdala, red; right amygdala, yellow; left HIPS, green) and group (experimental, control). The difference between the corresponding average fMRI percent signal change values for the experimental and control (sham) groups is also shown.