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. 2011 Sep 8;6(9):e24381. doi: 10.1371/journal.pone.0024381

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A. Principal components analysis (PCA) of the livers from mice at different life stages. The PCA shows the dramatic differences between the fetal/neonatal samples and the adult. More subtle differences were observed between adult and old mice (Not shown). C57, C57BL/6J; C3H, C3H/HeJ. B. Altered gene expression through life stages in the mouse liver. Differentially expressed genes (fold change≥|±2|) were identified and clustered as detailed in the Materials and Methods. There were no changes in gene expression in the “Adult” (PND67 and 6M) by definition. The intensity scale indicates fold-changes relative to the adult controls. Red, up-regulation; green, down-regulation; black, no change.