Table 1.
Simulation study: summary statistics based on 500 replicates
| Meta-analysis |
Intensity |
Integrative analysis |
||||||
| n | # clus | ρ | Lasso | Bridge | Lasso | Bridge | GLasso | Proposed |
| Correlation structure: Auto-regressive | ||||||||
| 50 | 50 | 0.30 | 179/16/44 | 135/15/42 | 43/16/33 | 28/14/28 | 38/20/31 | 22/19/30 |
| 50 | 50 | 0.70 | 130/23/34 | 105/21/31 | 53/20/21 | 34/18/16 | 26/23/19 | 23/21/14 |
| 100 | 50 | 0.30 | 162/29/36 | 150/26/34 | 36/23/25 | 31/21/21 | 76/24/22 | 46/24/17 |
| 100 | 50 | 0.70 | 145/26/24 | 93/26/21 | 52/25/16 | 36/22/12 | 48/24/13 | 44/24/8 |
| 50 | 250 | 0.30 | 94/7/48 | 59/5/46 | 58/13/37 | 41/11/34 | 54/18/30 | 40/18/31 |
| 50 | 250 | 0.70 | 152/15/40 | 124/13/38 | 38/16/21 | 33/15/18 | 39/20/21 | 36/19/16 |
| 100 | 250 | 0.30 | 160/17/42 | 71/13/40 | 53/21/26 | 44/20/23 | 32/23/24 | 30/22/23 |
| 100 | 250 | 0.70 | 147/27/27 | 90/20/25 | 29/21/16 | 28/21/13 | 30/24/14 | 29/22/9 |
| Correlation structure: Banded | ||||||||
| 50 | 50 | 0.20 | 189/22/34 | 102/15/32 | 52/19/19 | 33/16/16 | 25/22/18 | 25/22/13 |
| 50 | 50 | 0.33 | 162/16/38 | 92/12/36 | 32/17/24 | 26/15/20 | 31/19/24 | 29/18/22 |
| 100 | 50 | 0.20 | 139/29/24 | 89/26/21 | 50/22/15 | 36/21/12 | 44/22/12 | 40/22/7 |
| 100 | 50 | 0.33 | 149/28/29 | 95/25/26 | 26/21/20 | 25/21/15 | 59/23/16 | 45/23/11 |
| 50 | 250 | 0.20 | 129/20/40 | 125/18/38 | 39/15/20 | 32/13/17 | 38/21/19 | 36/20/16 |
| 50 | 250 | 0.33 | 100/18/44 | 95/16/44 | 47/14/27 | 36/13/23 | 46/17/26 | 44/17/24 |
| 100 | 250 | 0.20 | 134/22/26 | 86/21/23 | 27/20/15 | 26/19/13 | 27/23/14 | 25/22/9 |
| 100 | 250 | 0.33 | 72/18/34 | 59/16/32 | 36/20/21 | 29/19/17 | 32/24/19 | 30/24/14 |
| Correlation structure: Compound symmetric | ||||||||
| 50 | 50 | 0.30 | 175/21/34 | 87/19/32 | 34/18/22 | 26/16/18 | 31/19/21 | 30/18/16 |
| 50 | 50 | 0.70 | 119/21/22 | 79/20/20 | 45/16/14 | 29/13/12 | 41/16/13 | 38/16/8 |
| 100 | 50 | 0.30 | 106/26/26 | 72/23/22 | 32/23/18 | 29/22/14 | 57/25/14 | 45/25/9 |
| 100 | 50 | 0.70 | 150/25/17 | 99/23/15 | 27/21/12 | 32/19/9 | 68/24/9 | 52/24/4 |
| 50 | 250 | 0.30 | 71/12/40 | 62/11/40 | 44/17/23 | 36/15/20 | 80/20/22 | 48/19/21 |
| 50 | 250 | 0.70 | 107/15/28 | 66/12/24 | 28/14/15 | 26/13/11 | 88/18/15 | 55/17/11 |
| 100 | 250 | 0.30 | 112/25/31 | 116/22/28 | 36/23/18 | 35/23/15 | 27/25/17 | 27/25/12 |
| 100 | 250 | 0.70 | 149/26/19 | 105/22/15 | 61/21/12 | 34/18/10 | 50/24/10 | 46/23/5 |
n: sample size of each data set. # clus: number of gene clusters. ρ: correlation coefficient parameter. In cells with “a/b/c”: a is the number of genes identified, b is the number of true positives, and c is the number of prediction errors per 100 subjects.