Table 1.

Effect of NaHS (10⁻³ M) on spontaneous and stimulated contractile activity (after precontraction with bethanechol (3×10⁻⁶ M)) without and with antagonists of pathways potentially involved in the H_sS effect

Antagonist	Effect on spontaneous contractile activity†			Effect on stimulated contractile activity†
	Control response to NaHS	Response to NaHS with antagonist	p	Control response to NaHS	Response to NaHS with antagonist	p
NANC conditions	−47±14	−74±14 *	<0.02	-	-	-
TTX	−34±12	−81±8 *	<0.01	−62±7	−74±3 *	<0.05
Capsaicin	−34±12	−66±12 *	<0.01	−62±7	−69±8	0.09
L-NNA	−53±10	−77±10 *	<0.03	−69±9	−80±5 *	<0.01
Glibenclamide	−53±10	−68±6	0.23	−69±9	−42±7 *	<0.01

^†Percent change from baseline contractile activity; $\stackrel{‒}{x}\pm \mathrm{SEM}$; n=8 rats

^*Differs from control response under same condition (spontaneous or stimulated contractile activity; ANOVA)

NANC: non-adrenergic, non-cholinergic

TTX: tetrodotoxin

L-NNA: L-N^G-nitro arginine