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. 1998 Jul 1;12(13):2022–2035. doi: 10.1101/gad.12.13.2022

Figure 4.

Figure 4

 Interdependence and synergy between EGFR and Dpp signaling. Side views of 12- to 15-hr-old embryos stained with Lab antibody (A–D) or with LacZ antibody to visualize Ubx B expression (E–J): Wild type (A,E); 48Y.GAL4/UAS.Dpp (B); 48Y.GAL4/UAS.Dpp/UAS.DN-DER (C); 48Y.GAL4/UAS.Dpp/UAS.Dras1V12 (D); wild type (E); 24B.GAL4/UAS.DN-DER (F); 24B.GAL4/UAS.Dpp (G); 24B.GAL4/UAS.Dpp/UAS.DN-DER (H); 24B.GAL4/UAS.Dras1V12 (I); 24B.GAL4/UAS.Dpp/UAS.Dras1V12 (J). DN-DER antagonizes the stimulatory effects of Dpp in the anterior midgut (▵ in C,F,H; cf. with B,E,G, respectively), whereas Dras1V12 synergizes with Dpp [as judged by conspicuously strong and novel expression marked by arrowheads in D, J; cf. with the regions marked by asterisks (*) in B,G,I in which only low or no expression is seen in embryos expressing Dpp or Dras1V12 alone].