Table 2. Characteristics of breast cancer recurrence cases and matched breast cancer controls according to tumor and treatment variables and UGT genotypes.
| ER+/TAM+, n (%) | ER−/TAM− Group, n (%) | |||
|---|---|---|---|---|
| Cases | Controls | Cases | Controls | |
| UGT2B15*2 genotype | ||||
| 2 normal alleles | 151 (29) | 140 (27) | 85 (29) | 87 (30) |
| 1 variant allele | 237 (45) | 238 (46) | 133 (46) | 130 (45) |
| 2 variant alleles | 133 (26) | 139 (27) | 71 (25) | 69 (24) |
| (Missing) | 20 | 24 | 11 | 14 |
| UGT2B7*2 genotype | ||||
| 2 normal alleles | 127 (25) | 113 (22) | 53 (19) | 63 (22) |
| 1 variant allele | 224 (44) | 232 (46) | 142 (50) | 142 (50) |
| 2 variant alleles | 163 (32) | 162 (32) | 87 (31) | 77 (27) |
| (Missing) | 27 | 34 | 18 | 18 |
| UGT1A8*3 genotype | ||||
| 2 normal alleles | 502 (96) | 494 (95) | 284 (97) | 283 (97) |
| 1 variant allele | 19 (3.6) | 23 (4.4) | 8 (2.7) | 9 (3.1) |
| 2 variant alleles | 1 (0.2) | 1 (0.2) | 0 (0) | 0 (0) |
| (Missing) | 19 | 23 | 8 | 8 |
| CYP2D6 phenotype | ||||
| Normal function (2 normal alleles) | 299 (61) | 308 (62) | 167 (60) | 173 (62) |
| Reduced function (1 or 2 variant alleles) | 195 (39) | 189 (38) | 110 (40) | 107 (38) |
| Diagnosis year* | ||||
| 1985-1993 | 235 (43) | 234 (43) | 107 (36) | 100 (33) |
| 1994-1996 | 113 (21) | 112 (21) | 81 (27) | 83 (28) |
| 1997-2001 | 193 (36) | 195 (36) | 112 (37) | 117 (39) |
| Age at diagnosis, y | ||||
| 35-44 | 16 (3.0) | 13 (2.4) | 68 (23) | 58 (19) |
| 45-54 | 116 (21) | 111 (21) | 120 (40) | 113 (38) |
| 55-64 | 286 (53) | 281 (52) | 82 (27) | 86 (29) |
| 65-69 | 123 (23) | 136 (25) | 30 (10) | 43 (14) |
| Menopausal status at diagnosis* | ||||
| Premenopausal | 34 (6.3) | 34 (6.3) | 121 (40) | 121 (40) |
| Postmenopausal | 507 (94) | 507 (94) | 179 (60) | 179 (60) |
| UICC tumor stage at diagnosis* | ||||
| I | 9 (1.7) | 9 (1.7) | 25 (8.3) | 25 (8.3) |
| II | 250 (46) | 250 (46) | 153 (51) | 153 (51) |
| III | 282 (52) | 282 (52) | 122 (41) | 122 (41) |
| Histologic grade | ||||
| I | 108 (25) | 144 (35) | 27 (11) | 23 (10) |
| II | 234 (54) | 215 (52) | 125 (49) | 98 (43) |
| III | 92 (21) | 57 (14) | 103 (40) | 106 (47) |
| (Missing) | 107 | 125 | 45 | 73 |
| Type of surgery | ||||
| Mastectomy | 483 (89) | 470 (87) | 252 (84) | 244 (81) |
| Breast-conserving | 58 (11) | 71 (13) | 47 (16) | 56 (19) |
| (Missing) | 0 | 0 | 1 | 0 |
| Radiation therapy | ||||
| Yes | 183 (34) | 191 (35) | 128 (44) | 123 (47) |
| No | 358 (66) | 350 (65) | 166 (56) | 137 (53) |
| (Missing) | 0 | 0 | 6 | 40 |
| Adjuvant systemic chemotherapy | ||||
| Yes | 70 (13) | 65 (12) | 248 (83) | 188 (63) |
| No | 471 (87) | 476 (88) | 52 (17) | 112 (37) |
| ER expression at centralized re-assay | ||||
| Positive | 451 (92) | 474 (96) | 72 (26) | 70 (25) |
| Negative | 37 (7.6) | 19 (3.9) | 204 (74) | 205 (75) |
| Not available | 53 | 48 | 24 | 25 |
*
Variable used to match control subjects to recurrence cases using risk-set sampling.