Figure 8.

 Sister chromatid cohesion and condensation in vertebrate and yeast chromosomes. Hypothetical chromosome architecture of vertebrate (top) and yeast (bottom) chromosome is shown. In vertebrates, the major transition occurs at the onset of mitosis (G₂ to metaphase) when cohesion is largely reorganized and chromatids fully condense (top). In yeast, the structural reorganization of chromosomes takes place primarily at the metaphase–anaphase transition (bottom). Cohesins and condensins are shown by rectangles and circles, respectively. The single cohesion site drawn on the vertebrate metaphase chromosome by no means imply that cohesion is restricted to a centromeric region.