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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: J Immunol. 2011 Aug 10;187(6):3087–3095. doi: 10.4049/jimmunol.1003879

FIGURE 3. NK cells inhibit DC-mediated MHC class II-restricted priming of CD4+ T cells with tumor antigens but not soluble antigens.

FIGURE 3

CFSE-labeled OVA-specific OT-II (CD4+, I-Ab restricted) T cells were cocultured with splenic DCs and (A) γ-ray irradiated tumor cells (P815/t-OVA), or (B), soluble OVA protein (100 μg/ml). After 2.5 days, proliferation of CD4+ T cells was determined by flow cytometry. Numbers represent normalized percentage of proliferating T cells (no NK = 100%). Cumulative data from three independent experiments are shown as mean ± SEM. * p < 0.05.