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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Nat Med. 2011 Aug 21;17(9):1142–1146. doi: 10.1038/nm.2423

Figure 4. Comparison of AF680-ProT signal in FMT-CT studies of endocarditis in mice infected with S. aureus Newman or coagulase-deficient S. aureus Newman.

Figure 4

Non-invasive fluorescence molecular tomography fused to computed tomography (FMT-CT) of mice infected with (a) strain Newman or (b) Newman rendered genetically deficient in coagulases SC and VWbp. (c) Absolute fluorochrome concentration in vegetations quantified by FMT-CT. Data are mean ± SEM, n = 6 per group,* P < 0.01 (d) Kaplan-Meier curves comparing the survival of mice infected with Newman (blue line) or coagulase-deficient Newman (red line), n =10-13 per group, median survival 2.1 versus 4.3 days, P < 0.0001.