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. 2011 Mar 31;18(9):898–909. doi: 10.1038/gt.2011.37

Figure 2.

Figure 2

Antitumor effects and survival rate of tumor-bearing mice. Antitumor (a) and survival rate (b) in mice given PBS (⋄), RdB (□), RdB/IL-18 (⧫), RdB/IL-12 (▪) or RdB/IL-12/IL-18 (•). C57BL/6 tumor-bearing mice were treated with intratumoral injections of 1 × 108 plaque-forming unit per 30 μl of Ads on days 0, 2 and 4. Tumor volume was monitored on a 2-day interval until the end of the study. The arrow represents Ad inoculation. Values represent the mean±s.e.m. (6 animals per group). RdB/IL-12/IL-18-treated mice showed significantly enhanced antitumor effects and higher survival rates than did RdB/IL-12-treated mice. **P<0.01 vs RdB/IL-12-treated group.