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. 2011 Mar 31;18(9):898–909. doi: 10.1038/gt.2011.37

Figure 3.

Figure 3

RdB/IL-12/IL-18 treatment increased local expression of IL-12, IL-18, IFN-γ and GM-CSF in vivo. Tumor tissue was obtained 3 days after final viral treatment. ELISA was carried out to estimate the level of IL-12 (a), IL-18 (b), IFN-γ (c) and GM-CSF (d) in tumor tissues. Experiments were performed in triplicate and repeated three times. Each data point indicates means±s.e.m. of IL-12, IL-18, IFN-γ and GM-CSF levels for each individual tumor. RdB/IL-12/IL-18 produced a synergistically higher levels of IL-12, IL-18, IFN-γ and GM-CSF than RdB/IL-12 or RdB/IL-18 (Wilcoxon's signed-rank *P<0.05 compared with the sum of RdB/IL-12 or RdB/IL-18 alone).