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Increased Th1/Th2 cytokine ratio in tumor tissue treated with RdB/IL-12/IL-18. Tumor tissue was harvested 3 days after last viral injection. Th1/Th2/Th17 CBA assay was performed to determine the Th1/Th2 cytokine ratio in tumor tissues. (a) IFN-γ/IL-6 ratio. (b) Tumor necrosis factor-α/IL-6 ratio. Each data point indicates mean value±s.e.m. of triplicates of representative of three independent experiments. **P<0.01 vs RdB/IL-12-treated group.
