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. 2011 Sep 9;89(3):368–381. doi: 10.1016/j.ajhg.2011.07.025

Table 4.

Loci with Evidence of Selection in HapMap3

Chromosome Gene or Region SNP Position p Values
JPT-CH LWK-YRI CEU-TSI
2 LCT rs6754311 136424452 N/A 0.60 2.03 × 10−15
3 SLC9A9/Corf58 rs7649861 145653390 0.65 2.68× 10−7 0.04
6 HLA rs7745413 30023448 1.35 × 10−7 0.15 0.15
6 HLA rs28366191 32472168 0.08 0.23 0.69
6 HLA rs6901541 32550239 0.13 0.19 0.64
6 HLA rs2179915 33173712 N/A 1.08 × 10−3 0.87
7 CD36 rs12721454 79678275 N/A 2.63 × 10−5 0.40
7 CD36 rs513740 79872884 0.11 9.74 × 10−4 0.65
7 CD36 rs6944302 79942827 N/A 7.47 × 10−7 0.09
8 PSCA rs2976397 143761615 5.87 × 10−7 0.01 0.60
8 PSCA rs2920283 143754039 4.58 × 10−6 0.01 0.75
11 HBB+HBG2 rs7936387 5256204 N/A 0.66 N/A
11 OPCML rs11223548 133036865 8.90 × 10−7 0.90 N/A
12 KITLG rs11104947 87467111 4.88 × 10−7 N/A 0.43
15 OCA2 rs12913832 26039213 N/A N/A 1.42 × 10−8

We report all highly differentiated SNPs with strong or suggestive evidence for selection (p < 10−6). We see several well-studied examples of selection such as LCT, and OCA2 in Europeans, KITLG in East Asians, and CD36 in Africans. However, several markers significant in our original analysis of African populations do not appear significant in the LWK-YRI comparison. This may be because of the small sample size taken from each of the HapMap3 populations.