Table 4.
Chromosome | Gene or Region | SNP | Position |
p Values |
||
---|---|---|---|---|---|---|
JPT-CH | LWK-YRI | CEU-TSI | ||||
2 | LCT | rs6754311 | 136424452 | N/A | 0.60 | 2.03 × 10−15 |
3 | SLC9A9/Corf58 | rs7649861 | 145653390 | 0.65 | 2.68× 10−7 | 0.04 |
6 | HLA | rs7745413 | 30023448 | 1.35 × 10−7 | 0.15 | 0.15 |
6 | HLA | rs28366191 | 32472168 | 0.08 | 0.23 | 0.69 |
6 | HLA | rs6901541 | 32550239 | 0.13 | 0.19 | 0.64 |
6 | HLA | rs2179915 | 33173712 | N/A | 1.08 × 10−3 | 0.87 |
7 | CD36 | rs12721454 | 79678275 | N/A | 2.63 × 10−5 | 0.40 |
7 | CD36 | rs513740 | 79872884 | 0.11 | 9.74 × 10−4 | 0.65 |
7 | CD36 | rs6944302 | 79942827 | N/A | 7.47 × 10−7 | 0.09 |
8 | PSCA | rs2976397 | 143761615 | 5.87 × 10−7 | 0.01 | 0.60 |
8 | PSCA | rs2920283 | 143754039 | 4.58 × 10−6 | 0.01 | 0.75 |
11 | HBB+HBG2 | rs7936387 | 5256204 | N/A | 0.66 | N/A |
11 | OPCML | rs11223548 | 133036865 | 8.90 × 10−7 | 0.90 | N/A |
12 | KITLG | rs11104947 | 87467111 | 4.88 × 10−7 | N/A | 0.43 |
15 | OCA2 | rs12913832 | 26039213 | N/A | N/A | 1.42 × 10−8 |
We report all highly differentiated SNPs with strong or suggestive evidence for selection (p < 10−6). We see several well-studied examples of selection such as LCT, and OCA2 in Europeans, KITLG in East Asians, and CD36 in Africans. However, several markers significant in our original analysis of African populations do not appear significant in the LWK-YRI comparison. This may be because of the small sample size taken from each of the HapMap3 populations.