Figure 5.

Linearized ML Tree of HLA-C Alleles, Region of High Diversity Excluded

The scale bar indicates the number of substitutions (below) and time (MY) for a given length of the tree. The time estimate assumes that chimpanzee (specifically Patr-AB210183) and human HLA-C^∗07 alleles diverged as the species diverged about 6 MYA. The tree (log likelihood = −7378) is based on 3622 shared nucleotides after elimination of indels and the α1, α2, and RHD domains. Filled or open circles next to sequence names indicate, respectively, C1- or C2-type KIR-binding sites. Open horizontal bars represent the standard error estimate of the time of divergence of that node.