Table 2.

The proteasome inhibitor clastolactacystin β-lactone blocks centriole separation

Clastolactacystin β-lactone	Percent conversion
Extract alone	100
DMSO only	82
300 μm	79
450 μm	79
600 μm	47
800 μm	4

Results are presented as percent conversion (see Table 1), with numbers normalized to extract alone set at 100%. For clastolactacystin β-lactone, n = 2, range (at 800 μm) = <2%–4%. Lactacystin also inhibited centriole separation but was less effective.