Table 1.
Preferred regimens for the adjuvant treatment of early breast cancer
| TAC regimen88 |
| Docetaxel 75 mg/m2 day 1 |
| Doxorubicin 50 mg/m2 day 1 |
| Cyclophosphamide 500 mg/m2 day 1 |
| Every 21 days for six cycles |
| AC regimen89 |
| Doxorubicin 60 mg/m2 day 1 |
| Cyclophosphamide 600 mg/m2 day 1 |
| Every 21 days for four cycles |
| AC followed by paclitaxel regimen90–92 |
| Doxorubicin 60 mg/m2 day 1 |
| Cyclophosphamide 600 mg/m2 day 1 |
| Every 21 days for four cycles followed by paclitaxel 175 mg/m2 weekly for 12 weeks |
| Dose-dense AC followed by paclitaxel93 |
| Doxorubicin 60 mg/m2 day 1 |
| Cyclophosphamide 600 mg/m2 day 1 |
| Every 14 days for four cycles followed by paclitaxel 175 mg/m2 day 1 every 14 days for four cycles |
| AT regimen94 |
| Doxorubicin 60 mg/m2 day 1 |
| Docetaxel 60 mg/m2 day 1 |
| Every 21 days, for four cycles |
| TC regimen95 |
| Docetaxel 75 mg/m2 day 1 |
| Cyclophosphamide 600 mg/m2 day 1 |
| Every 21 days, for four cycles |
| EC regimen96 |
| Epirubicin 100 mg/m2 day 1 |
| Cyclophosphamide 830 mg/m2 day 1 |
| Every 21 days, for eight cycles |
| FAC regimen97,98 |
| 5-Fluorouracil 500 mg/m2 days 1 and 8 |
| Doxorubicin 50 mg/m2 day 1 |
| Cyclophosphamide 500 mg/m2 day 1 |
| Every 21 days, for six cycles |
| FEC regimen99 |
| 5-Fluorouracil 500 mg/m2 days 1 and 8 |
| Epirubicin 60 mg/m2 days 1 and 8 |
| Cyclophosphamide 75 mg/m2, po, days 1–14 |
| Every 21 days for six cycles |
| FEC followed by docetaxel100 |
| 5-Fluorouracil 500 mg/m2 day 1 |
| Epirubicin 100 mg/m2 day 1 |
| Cyclophosphamide 500 mg/m2 day 1 |
| Every 21 days, for three cycles followed by docetaxel 100 mg/m2 day 1 every 21 days for three cycles |
| FEC followed by paclitaxel101 |
| 5-Fluorouracil 600 mg/m2 day 1 |
| Epirubicin 90 mg/m2 day 1 |
| Cyclophosphamide 600 mg/m2 day 1 |
| Every 21 days, for three cycles followed by paclitaxel 100 mg/m2 weekly for eight weeks |
| CMF regimen |
| Cyclophosphamide 100 mg/m2, po, days 1–14 |
| Methotrexate 40 mg/m2 days 1 and 8 |
| 5-Fluorouracil 600 mg/m2 days 1 and 8 |
| Every 28 days, for six cycles |
Abbreviations: TAC, docetaxel-doxorubicin-cyclophosphamide; AC, doxorubicin-cyclophosphamide; AT, doxorubicin-docetaxel; TC, docetaxel-cyclophosphamide; EC, epirubicin-cyclophosphamide; FAC, 5-fluorouracil-doxorubicin-cyclophosphamide; FEC, 5-fluorouracil-epirubicin-cyclophosphamide; CMF, cyclophosphamide-methotrexate-5-fluorouracil; po, oral.