Table 3.

Adherence to antihypertensive medications and risk of all-cause death, stroke, and acute myocardial infarction, estimated in separate multivariable Cox proportional hazards models

	All-cause death		Stroke		Acute myocardial infarction
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Adherencea		<0.001b		0.381b		0.877b
Poor	1.00		1.00		1.00
Moderate	0.81 (0.66–0.99)	0.038	0.96 (0.69–1.33)	0.799	1.14 (0.71–1.83)	0.592
Good	0.59 (0.48–0.72)	<0.001	0.81 (0.59–1.11)	0.197	0.98 (0.62–1.55)	0.939
Excellent	0.37 (0.31–0.45)	<0.001	0.82 (0.63–1.07)	0.138	0.96 (0.65–1.40)	0.825

Notes: Totals of 768 deaths in 30,668 subjects and 370 strokes and 191 acute myocardial infarctions in 31,340 subjects were considered in the models; HRs with 95% CIs adjusted for age, gender, and use of hypoglycemic agents, lipid-lowering agents, cardiac therapy, and platelet aggregation inhibitors before the enrolment date;

^adefined as in Table I;

^bfor trend.

Abbreviations: CI, confidence interval; HR, hazard ratio.