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. Author manuscript; available in PMC: 2011 Sep 9.
Published in final edited form as: J Immunol. 2010 Mar 10;184(8):4378–4390. doi: 10.4049/jimmunol.0903416

FIGURE 7.

FIGURE 7

Neutralization of IL-22 reduces T. gondii-associated intestinal pathology and mortality. Mice were infected orally with 20, 50, or 100 cysts of T. gondii (ME49 strain) as indicated. One of two experiments, with five mice per group, is shown. Data are shown as mean ± SEM (A, D) with representative images (B). Groups of mice were given 1 mg/wk anti–IL-22 or control Ab (isotype) i.p. from day 1 until day 35. *p < 0.05. A, Weight loss at day 10 post-infection with 50 T. gondii cysts. B, Kaplan–Meier graph showing percentage survival following oral T. gondii infection with mice treated with anti–IL-22 from day 1 to day 30. C, H&E-stained section of the small intestine at day 8 after oral infection with 50 T. gondii cysts (original magnification ×100). D, Expression of il17a, il17f, il22, tnfα, ifnγ, mig (cxcl9), kc (cxcl1), il10, arg1, and il13 mRNA in the ileum of infected mice at day 9 of mice infected with 50 cysts.