Fig. 3.

Schematic illustrating the process of design incorporating solvation of the ligand. The symbols HR₁ and HR₂ represent functional group positions. The symbol W₁ represents a growable water position from a hydrogen-bond donor and the symbol W₂ represents a growable water position from a hydrogen-bond acceptor. Wavy lines indicate a potential bond and dashed lines indicate a hydrogen bond. The first stage of design involves growing functional groups (a) and the second involves growing water molecules (b).