Skip to main content
. 2011 Aug 22;24(10):801–809. doi: 10.1093/protein/gzr041

Table I.

Ninety-five percent conserved residues among the 84 Class D sequences

3ISG sequence #s 3ISG PDB #s Function/comment
Pro44 Pro65
Ser46a Ser67b Nucleophile that attacks β-lactam
Thr47 Thr68b
Phe48 Phe69b
Lys49a Lys70b General base
Ser93a Ser115c
Gly106 Gly128
Tyr119 (some Phe) Tyr141d Ω-loop Class D motif
Gly120a Gly142d Ω-loop Class D motif
Asn121 Asn143d Ω-loop Class D motif
Trp138a Trp160e Interacts with general base
Ile145 Ile167 Val makes up the remainder
Leu162 Leu184 Val, Phe make up the remainder
Lys190a Lys212f Likely proton donor
Gly192a Gly214f Mainchain amide contributes to oxyanion hole
Trp205a Trp228 Part of hydrophobic core
Gly208a Gly231
Phe220a Phe243

aStrictly conserved.

fKTG family signatures (Paetzel et al., 2000).