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. Author manuscript; available in PMC: 2011 Sep 9.
Published in final edited form as: Neuroscience. 2009 Oct 9;165(3):882–895. doi: 10.1016/j.neuroscience.2009.10.007

Figure 5. Morphine analgesia in two lines of KEPI KO mice.

Figure 5

(a) In both, tail flick (MANOVA p < 0.001 for the effect of genotype, p < 0.005 for genotype * dose interaction) and hot plate (MANOVA p < 0.05 for the effect of genotype) assays, the original KEPI KO mice were more sensitive to morphine analgesia then their WT littermates. (b) There was no significant difference between the two genotypes from the recombinant line. MPE, maximal possible effect. Data are expressed as means ± SEM (n = 12 per group).