Skip to main content
. Author manuscript; available in PMC: 2011 Sep 9.
Published in final edited form as: Neuroscience. 2009 Oct 9;165(3):882–895. doi: 10.1016/j.neuroscience.2009.10.007

Figure 6. Development of morphine tolerance and dependence in the recombinant KEPI KO mice.

Figure 6

(a) In the tail flick assay, responses to 8 mg/kg morphine were identical between the WT and KO animals. (b) In the hot plate assay, tolerance to morphine developed faster in the KO mice. MPE, maximal possible effect. (MANOVA p < 0.05 for genotype; and p<0.05 for genotype * day;

n = 12per group). Data are expressed as means ± SEM.