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. Author manuscript; available in PMC: 2011 Sep 9.
Published in final edited form as: Neuroscience. 2009 Oct 9;165(3):882–895. doi: 10.1016/j.neuroscience.2009.10.007

Figure 7. Naloxone-precipitated withdrawal in two lines of KEPI KO mice.

Figure 7

(a) After 8 days of twice-daily morphine treatment, females from the original line exhibited significantly less naloxone-precipitated jumping than the males (ANOVA p<0.01; n = 6–7 per group). (b) In the recombinant line, sex had no effect on this behavior (n = 17 per group). There was no difference between the genotypes in either of the two lines. Data are expressed as means ± SEM.