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. Author manuscript; available in PMC: 2011 Sep 9.
Published in final edited form as: Neuroscience. 2009 Oct 9;165(3):882–895. doi: 10.1016/j.neuroscience.2009.10.007

Figure 8. Morphine conditioned place preference and locomotion in the recombinant KEPI KO mice.

Figure 8

(a) KEPI homozygote knockouts displayed a rightward shift in the dose-response curve for morphine conditioned place preference when compared to WT animals. Heterozygote knockouts showed an intermediate phenotype (Linear Regression p = 0.001 for genotype * dose interaction). (b) There was no difference in morphine-induced locomotion as recorded during the first conditioning session. Data are expressed as means ± SEM (n = 12 per group).