Table 2. Behavioral phenotype of the original KEPI mice.
Number of subjects is in brackets.
| Age | Sex | +/+ | +/− | −/− | P | |||
|---|---|---|---|---|---|---|---|---|
| Motor functions | ||||||||
| latency to fall off of an accelerating rotarod (s) | 3 M | M, F | 220 (33) | 231 (21) | 221 (26) | 0.52 | ||
| 6 M | M, F | 185 (22) | 164 (24) | 176 (33) | 0.84 | |||
| 12 M | M, F | 150 (20) | 127 (19) | 168 (18) | 0.53 | |||
| Learning in Morris Water Maze | ||||||||
| Latency to platform quadrant (s) | 2–3 M | M, F | 4.4 (16) | 2.8 (15) | 2.4 (14) | 0.03* | ||
| Latency to new location (s) | 2–3 M | M, F | 2.2 (16) | 1.9 (15) | 1.2 (14) | 0.41 | ||
| Time in new/time in old | 2–3 M | M, F | 5.5 (16) | 8.9 (15) | 5.9 (14) | 0.24 | ||
| Anxiety & Stress-Induced Anxiety | ||||||||
| Dark box | - Latency to emerge (s) | baseline | 2–3 M | M, F | 59 (15) | 80 (16) | 111 (16) | 0.68 |
| stress | 2–3 M | M, F | 410 (16) | 415 (16) | 344 (12)) | 0.68 | ||
| - Time outside (s) | baseline | 2–3 M | M, F | 188 (15)) | 161 (16) | 159 (16) | 0.77 | |
| stress | 2–3 M | M, F | 115 (16) | 107 (16) | 118 (16) | 0.98 | ||
| Open field | - Time in center (s) | baseline | 2–3 M | M, F | 62 (16) | 59 (16) | 56 (16) | 0.91 |
| stress | 2–3 M | M, F | 24 (14) | 23 (15) | 27 (15) | 0.09 | ||