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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Nature. 2011 Aug 31;477(7362):90–94. doi: 10.1038/nature10357

Figure 3. Systemic chemokine levels increase during aging and heterochronic parabiosis and correlate with decreased neurogenesis.

Figure 3

a, Venn diagram of results from aging and parabiosis proteomic screens. Seventeen age-related plasma factors correlated strongest with decreased neurogenesis in gray, fifteen plasma factors increased between young isochronic and young heterochronic parabionts in red, and six factors elevated in both screens in brown intersection. Data from 5–6 animals per age group. b,c Changes in plasma concentrations of CCL11 with age (b) and young heterochronic parabionts pre- and post- parabiotic pairing (c). d,e Changes in plasma (d) and CSF (e) concentrations of CCL11 with age in healthy human subjects. All data represented as dot plots with mean; *P< 0.05; **P< 0.01; ***P< 0.001 t-test (c,e), ANOVA, Tukey’s post-hoc test (a,b), and Mann-Whitney U Test (d).