Fig. 6.

(A) Comparison of the replication profile and the mutation rate profile of Chromosome VI. Replication profile from Raghuraman et al. (2001). Both axes are linear and the range of mutation rates and replication times is the same as in figure 4D. A blue arrow below the mutation rate plot indicates the location selected to test mutation rate before and after ARS607 disruption. A green arrow above the mutation rate plot indicates the locations selected to test mutation rate following the deletion of rev1 (see fig. 7) (B) Autonomously replicating sequences on Chromosome VI. Positions and efficiencies from the Saccharomyces Genome Database (http://www.yeastgenome.org). Position is the distance from the left telomere and efficiency is the fraction of cell divisions in which the origin fires. Replication timing from Raghuraman et al. (2001). ARS601 and ARS602 overlap and comprise one origin; ARS600 and ARS610 are subtelomeric.