Table 1.

Originally Published^a and Adjusted Odds Ratios of the Association Between ART and Major Malformations

Reference & study typeb	Originally published odds ratio	Significance	Adjusted odds ratio	Significance
4 C	0.54	P < .05	0.38	P < .05
12 V	0.81	NS	0.59	P < .05
2 C	0.77	NS	0.64	NS
18 V	0.86	NS	0.79	P < .05
20 V	0.90	NS	0.84	NS
15 V	1.00	NS	1.00	NS
13 V	1.04	NS	1.02	NS
3 X	1.07	P < .05	1.05	NS
19 C	1.24	NS	1.07	NS
9 V	1.21	NS	1.11	NS
6 V	1.19	P < .05	1.12	NS
16 V	1.29	NS	1.13	NS
7 V	1.25	NS	1.17	NS
10 X	1.27	P < .05	1.18	P < .05
17 V	1.38	NS	1.18	NS
5 X	2.05	P < .05	1.69	P < .05
8 C	2.23	P < .05	1.82	P < .05
14c V	15.4	NS	5.4	NS
Overall Odds Ratiod	1.14e	P < .05	1.01	NS

^a18 of the original studies are shown here; as explained in the text, one study has been removed.

^bReference numbers refer to references in this publication, not the original publication. V: IVF Study; X: ICSI Study; C: Combined Results of ICSI and IVF.

^cNo MM in control group; when .5 is substituted for zero, the adjusted OR is 5.4.

^dSince the odds ratios in our meta-analysis were not significantly different for IVF versus ICSI and for singleton versus multiple, the data were pooled to obtain an overall odds ratio.

^eOverall odds when 18 studies included.