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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Mol Oral Microbiol. 2011 Jul 19;26(5):303–320. doi: 10.1111/j.2041-1014.2011.00619.x

Figure 1.

Figure 1

LTM pathway containing genes differentially regulated by polymicrobial infection with P. gingivalis+T. denticola+T. forsythia in calvarial bone compared to sham-infected controls at P ≤ 0.05, adapted from PATHWAY EXPRESS and using the Kyoto Encyclopedia of Genes and Genomes nomenclature. Genes shown in red are upregulated, genes shown in blue are downregulated, and green indicates no change in gene expression at the P < 0.05 significance level. +p = phosphorylation event; -p dephosphorylation event; ? = receptors that are yet to be identified; and O = other molecule. An arrow indicates a molecular interaction resulting in transendothelial migration, leukocyte activation, regulation of actin cytoskeleton and a line without an arrowhead indicates a molecular interaction resulting in inhibition.