Extracelular Membrane receptor interaction pathway containing genes differentially regulated by polymicrobial infection with P. gingivalis+T. denticola+T. forsythia in calvarial bone compared to sham-infected controls at P ≤ 0.05. An arrow indicates a molecular interaction resulting in ECM-receptor activation, regulation of integrin (VLA proteins, leukoproteins, cytoadhesin, focal adhesion, proteoglycan, glycoprotein).