Table 1.
Demographics, clinical characteristics, and genotype distributions in the four cohorts.
| Cohort | Age (median) | Sex | Race | HIV viral load (median) | HIV risk factor | C/C | C/T | T/T | C allele frequency | T allele frequency |
|---|---|---|---|---|---|---|---|---|---|---|
| NVS n= 48 | 49 (range 30–68) | 50% M 50% F | 100% AA | <50 (range <50 to 273) | 54% IDU 46% S | 12.5% | 54.2% | 33.3% | 39.6% | 60.4% |
| LVL n= 34 | 46 (range 21–63) | 53% M 47% F | 100% AA | 3080 (range 233–19,600) | 39% IDU 61% S | 14.7% | 52.9% | 32.4% | 41.1% | 58.9% |
| MHVL n= 90 | 48 (range 22–60) | 54% M 46% F | 100% AA | 100,000 (range 24,584–667,000) | 38% IDU 62% S | 17.8% | 47.8% | 34.4% | 41.7% | 58.3% |
| HIV negative n= 173 | 50 (range 27–70) | 35% M 65% F | 100% AA | N/A | 55% IDU* | 11.6% | 54.9% | 33.5% | 39% | 61% |
Demographics and frequency of the C/C, C/T, and T/T alleles for SNP rs12979860 of the NVS and other cohorts. There was no statistically significant difference among any of the four cohorts by recessive, allelic, and dominant models. By the recessive model, p= 0.48 between the NVS and non‐NVS HIV groups, and p= 0.85 between the NVS and HIV‐negative group by Fisher’s exact test. NVS (natural viral suppressors) = HIV‐1 patients with viral loads <400 copies/mL without treatment. LVL (Low Viral Load) = HIV‐1 patients viral loads 500–20,000 copies/mL without antiretrovirals. MHVL (Medium/High Viral load) = HIV‐1 patients with viral loads >20,000 copies/mL. HIV negative = HIV‐1 negative and HCV positive race‐matched (African American) control cohort. M = male, F = female, AA = African American. IDU = injection drug use, S = sexual.
*A total of 55% of the HIV‐negative group had a history of IDU.