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. Author manuscript; available in PMC: 2011 Sep 9.
Published in final edited form as: Sci Transl Med. 2010 Nov 3;2(56):56ra81. doi: 10.1126/scitranslmed.3001417

Fig. 3.

Fig. 3

Accumulation of non-enzymatic cholesterol oxidation products in Npc1−/− mouse tissues.

(A,B) Oxysterol concentrations in livers of 9-week-old WT and Npc1−/− mice. (C) 3β,5α,6β-triol concentrations in the brain tissue of 9-week-old WT and Npc1−/− mice. (D) 3β,5α,6β-triol concentrations in cerebellar tissue of 10 day, 4-week and 7-week-old WT and Npc1−/− mice. (E) 24(S)-HC concentrations in the brain tissue of 9-week-old WT and Npc1−/− mice. Error bars represent samples from independent mice as denoted in each panel. *p<0.05 and **p<0.001 for Npc1−/− vs. WT.