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Comparison of plasma oxysterol concentrations in NPC1 disease and other lysosomal storage diseases.
(A) 3β,5α,6β-triol, (B) 7-KC and (C) 24(S)-HC concentrations in fasting plasma samples from control, NPC1, infantile neuronal ceroid lipofuscinosis (INCL), GM-1 gangliosidosis (GM-1), GM-2 gangliosidosis (GM-2) and Gaucher disease (GD) subjects. For 3β,5α,6β-triol, p<0.001 for NPC1 vs. INCL, GM-1, GM-2 and GD; for 7-KC, p<0.001 for NPC1 vs. GM-1 and GM-2 and p<0.01 for NPC1 vs. INCL
