Table 3.

Drug interactions with chloroquine.

Drug	Type	Interaction with chloroquine	Clinical significance
Chlorpromazine	Antipsychotics	Chloroquine, SP and amodiaquine increase serum concentrations of chlorpromazine 1.7 – 4.3 times [131]	Unknown
Cimetidine	Histamine h2-receptor antagonist	Cimetidine increases serum concentration of chloroquine prolonging its half-life 48% [132]	Unknown
Codeine	Opiate	Chloroquine inhibits CYP2D6 and may theoretically interfere with bio-activation of codeine to morphine [133]	Unknown
Cyclosporine	Immunosuppressant	Cyclosporine concentrations increase up to 4.3 times when used with chloroquine [134]	Cyclosporine dosages may need to be reduced during concomitant chloroquine use
Kaolin-Pectin	Antidiarrhoeal	Kaolin–Pectin reduces the area under the plasma-chloroquine concentration–time curve by ∼ 30% [135]	Unknown
Methotrexate	Antimetabolite and antifolate	Methotrexate peak concentrations are reduced 20% and its area under the concentration–time curve is reduced 28% with concomitant chloroquine use [136]	Unknown
Praziquantel	Anthelmintic	Concomitant use of chloroquine reduces concentration–time curve of praziquantel 65% and peak concentrations 59% [109]	WHO recommends inclusion of pregnant women in deworming campaigns with 40 mg/kg praziquantel [110]