Table 1.
Function domains identified for the two SI-involved candidate genes Can3 and Can94 by comparing their translated ORFS with the InterPro database* for protein function prediction
| Name | Amino acids | InterPro entry | Function domain |
|---|---|---|---|
| Can3, ORF1 (261 amino acids, nt 802–1587) | 1–71 | IPR000719 | Protein kinase, catalytic domain |
| 112–172 | IPR004041 | NAF domain | |
| 21–242 | IPR020636 | Calcium/calmodulin-dependent protein kinase-like | |
| Can3, ORF2 (216 amino acids, nt 218–868) | 12–216 | IPR000719 | Protein kinase, catalytic domain |
| 60–215 | IPR020636 | Calcium/calmodulin-dependent protein kinase-like | |
| 193–213 | n.a. | Transmembrane-region | |
| Can94 (248 amino acids, nt 169–915) | 1–228 | IPR020636 | Calcium/calmodulin-dependent protein kinase-like |
| 68–96 | IPR002048 | Calcium-binding EF-hand | |
| 104–132 | IPR002048 | Calcium-binding EF-hand | |
| 140–168 | IPR002048 | Calcium-binding EF-hand | |
| 173–201 | IPR002048 | Calcium-binding EF-hand |
* http://www.ebi.ac.uk/Tools/InterProScan/. The Can3 transcript contains two slightly overlapping ORFs of 261 and 216 amino acids in length which were analysed independently.