Table 4.
Mean scores before the radiotherapy, change of scores between before and the last week of radiotherapy and responsiveness statistics in patients who perceived improved health (n = 22)
| n | Score before radiotherapy Mean (SDa) | Difference Mean (SDa) | Pb | SRMc (CI 95%) | ESd (CI 95%) | |
|---|---|---|---|---|---|---|
| EORTC QLQ-C30: | ||||||
| Functional scalese : | ||||||
| Physical function | 22 | 83.9 (18.4) | -6.5 (16.4) | 0.08 | - 0.39 (-0.78;0.02) | - 0.35 (-0.85;0.21) |
| Role function | 21 | 74.6 (27.2) | -6.3 (28.1) | 0.07 | - 0.22 (-0.74;0.22) | -0.23 (-0.78;0.21) |
| Emotional function | 22 | 79.2 (17.8) | +3.8 (14.2) | 0.23 | 0.26 (-0.19;0.67) | 0.21 (-0.15;0.57) |
| Cognitive function | 22 | 94.7 (7.9) | -4.5 (15.6) | 0.19 | - 0.29 (-0.67;0.17) | - 0.57 (-0.55;0.21) |
| Social function | 22 | 78.8 (24.2) | -5.3 (22.0) | 0.27 | - 0.24 (-0.69;0.21) | - 0.21 (-0.78;0.16) |
| Global QoL/GHS | 22 | 54.9 (22.7) | +5.7 (26.4) | 0.32 | 0.21 (-0.32;0.53) | 0.25 (-0.24;0.75) |
| Symptom scalesf : | ||||||
| Fatigue | 22 | 38.9 (25.1) | +2.0 (28.4) | 0.74 | 0.07 (-0.37;0.56) | 0.08 (-0.37;0.70) |
| Pain | 22 | 23.5 (23.9) | +8.3 (27.6) | 0.17 | 0.30 (-0.16;0.84) | 0.34 (-0.16;1.04) |
| Nausea and vomiting | 22 | 2.3 (7.8) | +3.0 (12.2) | 0.26 | 0.24 (-0.21;0.70) | 0.38 (-0.75;1.33) |
| Single itemsf : | ||||||
| Dyspnoea | 21 | 11.1 (16.1) | 0.0 (14.9) | 1.00 | 0.0 (-0.52;0.44) | 0.0 (-0.41;0.38) |
| Sleep disturbance | 22 | 28.8 (34.6) | -7.6 (35.5) | 0.33 | - 0.21 (-0.62;0.30) | - 0.21 (-0.64;0.30) |
| Appetite loss | 21 | 20.6 (28.8) | +4.8 (35.4) | 0.54 | 0.13 (-0.31;0.66) | 0.16 (-0.32;0.91) |
| Diarrhoea | 22 | 28.8 (31.4) | -1.5 (33.3) | 0.83 | - 0.04 (-0.56;0.39) | - 0.04 (-0.48;0.56) |
| Constipation | 22 | 15.2 (24.6) | +12.1 (24.2) | 0.03 | 0.50 (0.06;0.97) | 0.49 (0.06;1.20) |
| Financial impact | 21 | 10.6 (26.0) | +5.7 (26.4) | 0.33 | 0.22 (0.17;0.31) | 0.06 (-0.15;0.24) |
| EORTC QLQ-CR38: | ||||||
| Functional scalese : | ||||||
| Body image | 20 | 90.9 (16.3) | -3.3 (14.5) | 0.32 | - 0.23 (-0.7;0.27) | - 0.20 (-0.81;0.50) |
| Future perspective | 21 | 56.1 (26.0) | +4.8 (21.8) | 0.33 | 0.21 (-0.23;0.72) | 0.18 (-0.21;0.57) |
| Sexual functioning | 20 | 16.7 (27.9) | -5.8 (21.8) | 0.24 | - 0.26 (-0.76;0.19) | - 0.20 (-0.54;0.17) |
| Sexual enjoyment | 10 | 33.3 (49.4) | -26.7 (30.6) | 0.02 | - 0.87 (-1.79;-0.45) | - 0.53 (-1.03;-0.15) |
| Symptom scalesf : | ||||||
| Radiation-induced effects micturition | 21 | 21.7 (22.6) | +19.3 (21.9) | 0.0006 | 0.88 (0.42;1.44) | 0.85 (0.36;1.50) |
| Chemotherapy side effects | 21 | 15.2 (23.6) | +5.3 (13.0) | 0.08 | 0.40 (-0.11;0.89) | 0.22 (-0.15;0.55) |
| General Gastrointestinal symptoms | 21 | 26.7 (14.9) | -0.4 (11.9) | 0.88 | - 0.03 (-0.50;0.46) | 0.02 (-0.38;0.36) |
| Defecation problems | 19 | 37.6 (21.6) | -1.5 (14.8) | 0.66 | - 0.10 (-0.59;0.41) | - 0.07 (-0.42;0.27) |
| Stoma-related problems | 1 | 9.5 (00.0) | +23.8 (-) | - | - | - |
| Sexual dysfunction of men | 9 | 35.9 (44.5) | +7.4 (20.6) | 0.31 | 0.35 (-0.28;1.09) | 0.16 (-0.09;0.65) |
| Sexual dysfunction of women | 2 | 16.7 (23.6) | +16.7 (0.0) | 1.00 | 0 | 0.70 (0.65;1.10) |
| Weight loss | 21 | 28.8 (34.6) | +1.6 (38.7) | 0.85 | 0.04 (-0.40;0.55) | 0.04 (-0.43;0.67) |
| FACT-Ce : | ||||||
| Physical Well-Being | 19 | 81.4 (16.4) | -5.0 (14.3) | 0.15 | - 0.34 (-0.77;0.17) | - 0.30 (-0.94;0.10) |
| Social/Family Well-Being | 19 | 71.3 (25.7) | -7.4 (16.2) | 0.06 | - 0.45 (-0.96;0.09) | - 0.28 (-0.63;0.03) |
| Emotional Well-Being | 19 | 77.5 (17.6) | 0 (12.7) | 1.00 | 0.0 (-0.78;0.31) | 0.0 (-0.34;0.37) |
| Functional Well-Being | 18 | 50.1 (20.0) | -2.5 (17.1) | 0.55 | - 0.14 (-0.71;0.40) | - 0.12 (-0.56;0.35) |
| Colorectal Cancer Specific | 19 | 67.7 (11.5) | -3.2 (12.3) | 0.27 | - 0.26 (-0.64;0.24) | - 0.28 (-0.80;0.18) |
| FACT-C total score | 19 | 69.1 (11.4) | -3.0 (8.5) | 0.14 | - 0.35 (-0.96;0.19) | - 0.26 (-0.64;0.15) |
| Trial Outcome Index-Colorectal | 19 | 65.7 (13.7) | -2.6 (10.2) | 0.29 | - 0.25 (-0.78;0.31) | - 0.18 (-0.60;0.20) |
a Standard Deviation. b Wilcoxon test of the change. c Standardized Response Mean. d Effect Size.
e Higher score indicates a higher level of functioning or better quality of life. f Higher score indicates more symptoms/problems. Bold indicate p values < 0.05.