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. 2011 Aug 2;7:1064–1069. doi: 10.3762/bjoc.7.122

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Copyright © 2011, Nagaki et al.

This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)

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Flow microreactor system for halogen–lithium exchange of aryl halide followed by reaction with methanol. T-shaped micromixer: M1 (inner diameter: 250 μm), and M2 (inner diameter: 500 μm), microtube reactor: R1 and R2 ( = 1000 μm, length = 50 cm), a solution of aryl halides: 0.10 M in THF (6.0 mL/min), a solution of lithium reagent: 0.40 M or 0.42 M in hexane (n-BuLi) or Et₂O (PhLi) (1.5 mL/min), a solution of methanol: Neat (3.0 mL/min).

Inline graphic — Flow microreactor system for halogen–lithium exchange of aryl halide followed by reaction with methanol. T-shaped micromixer: M1 (inner diameter: 250 μm), and M2 (inner diameter: 500 μm), microtube reactor: R1 and R2 ( = 1000 μm, length = 50 cm), a solution of aryl halides: 0.10 M in THF (6.0 mL/min), a solution of lithium reagent: 0.40 M or 0.42 M in hexane (n-BuLi) or Et₂O (PhLi) (1.5 mL/min), a solution of methanol: Neat (3.0 mL/min).