Table 2.
Distribution of TP53 codon 72 and MDM2 SNP309 genotypes in HCC cases and controls
| HCC Cases (n = 61) n (%) |
Controls (n = 122) n (%) |
ORa (95% CI) | P Valueb | |
|---|---|---|---|---|
| TP53 codon 72 | ||||
| Pro Allele | 27(22.1) | 60(24.6) | 1 | |
| Arg Allele | 95(77.9) | 184(75.4) | 1.15(0.7-2.0) | 0.695 |
| Pro/Pro | 3(4.9) | 9(7.4) | 1 | |
| Pro/Arg | 20(32.8) | 42(34.4) | 0.96(0.2-4.3) | 0.875 |
| Arg/Arg | 38(62.3) | 71(58.2) | 1.20(0.3-5.0) | 0.716 |
| Arg/Arg + Pro/Arg | 58(95.1) | 113(92.6) | 1.12(0.3-4.5) | 0.751 |
| MDM2 SNP309 | ||||
| T Allele | 58(47.5) | 154(63.1) | 1 | |
| G Allele | 64(52.5) | 90(36.9) | 1.89(1.2-3.0) | 0.006 |
| T/T | 13(21.3) | 55(45.1) | 1 | |
| T/G | 32(52.5) | 48(39.3) | 2.82(1.3-6.4) | 0.010 |
| G/G | 16(26.2) | 19(15.6) | 3.56(1.3-9.7) | 0.009 |
| G/G + T/G | 48(78.7) | 67(54.9) | 3.03(1.4-6.6) | 0.003 |
aT allele or T/T MDM2 SNP309 and TP53 Pro allele or Pro/Pro codon 72 genotypes were considered as the baseline when calculating the relative crude ORs.
bYates corrected P values