Table 2.

Initial RoPE Variables of Interest

Variable Type	Variable
Clinical	Age
	Gender
	Race
	History of the following (prior to index stroke)
	Migraines
	Hypertension
	Diabetes
	Prior cerebral ischemia
	Coronary artery disease
	Obesity
	Hypercholesterolemia
	Smoking status
	Antithrombotic medications
	Deep vein thrombosis
	Pulmonary Embolism
	Hypercoagulable states
	Antithrombotic medications after index event
	Outcome: National Institutes of Health Stroke Severity Score
Echocardiographic	Hypermobility of interatrial septum ("ASA")
	Interatrial shunting at rest (e.g. not during Valsalva maneuvers)
	Volume of interatrial shunt (e.g. max. bubbles in left atrium)
	Anatomical PFO size
	Spontaneous Doppler flow seen on color
Radiological	MRI/CT findings of cerebral infarct: yes/no (at index stroke)
	Number of prior cerebral infarcts
	Anatomical location of index and prior infarct(s)