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Induction of aberrant anaphase mitoses events by mutant TERT proteins
| Cell line
|
Induction
|
No. of cells examined
|
Fraction with aberrant eventsa (%)
|
|---|---|---|---|
| A431-EcR | − | 50 | 16 |
| A431-EcR | + | 50 | 16 |
| A431-wt TERT | − | 50 | 15 |
| A431-wt TERT | + | 50 | 16 |
| A431-dn TERT | − | 50 | 14 |
| A431-dn TERT | + | 60 | 58 |
Fraction of aberrant anaphase mitoses were determined by calculating the ratio of mitosis events showing either chromosome bridges or lagging chromosomes to the total mitosis events observed.
