Table 3.
Myeloperoxidase (MPO) activity in the jejunum segment from inducible nitric oxide synthase knock-out mice (iNOS-/-) and C57BL/6 wild-type animals (iNOS+/+) submitted to intestinal mucositis
| iNOS+/+/control | iNOS+/+/MTX | iNOS-/-control | iNOS-/-/MTX | |
|---|---|---|---|---|
| Mean ± Std. error | 0.056 ± 0.01 | 8.45 ± 0.60 * | 0.035 ± 0.02 | 0.056 ± 0.001 |
Intestinal mucositis was induced by subcutaneous administration of MTX. After sacrifice, on the 5th day, a sample of the jejunum segment was harvested for MPO activity assay. *p < 0.05 represents statistical differences compared to iNOS+/+/control group. The number of animals in each group was at least four. Data were analyzed by using analysis of variance (ANOVA) and Bonferroni tests.