Table 1.
The co-distribution of a risk marker (High/Low risk) and adverse event (+/- Toxicity) in response to standard treatment in two hypothetical patient populations (A, B).
| Population A | Outcome | Low risk | High risk |
|---|---|---|---|
| RR/OR | - Toxicity | 969 | 20 |
| 9.9/10.8 | +Toxicity | 9 | 2 |
| Precision 2/(20+2): 9.1% | Sensitivity 2/(9+2): 18% | ||
| Population B | Outcome | Low risk | High risk |
| RR/OR | - Toxicity | 535 | 446 |
| 9.9/10.2 | +Toxicity | 2 | 17 |
| Precision 17/(446+17): 3.7% | Sensitivity 17/(2+17): 89% | ||
Precision and sensitivity calculated as explained in the main text. RR: Relative Risk; OR: Odds Ratio