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Amino acid sequence alignment of the RNase domains of hIRE1α, mIRE1β, C. elegans IRE1, S. cerevisiae IRE1 and human RNase L. The conserved residues are shaded. Dashes represent gaps between residues to obtain maximal matching. Mutations that disrupt (filled circle) or do not effect (*) RNase activity are indicated. Numbers on the right are the position of the last amino acid.
