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. 1999 Sep 15;13(18):2412–2424. doi: 10.1101/gad.13.18.2412

Figure 6.

Figure 6

Figure 6

RANK−/− mice show normal DC development and function. (A) The allostimulatory capacity of CD11c+ DCs from untreated RANK+/+ (█) and RANK−/− (●) mice was measured in a mixed lymphocyte reaction (MLR) as described in Materials and Methods. Values represent the mean ± s.e.m. of triplicate cultures and are representative of experiments from multiple mice (n = 3). (B) Flow cytometric analysis of splenic DCs from FL-treated RANK+/+ (left) and RANK−/− (right) animals. Mice were treated with FL for nine days (see Materials and Methods) to mobilize DC, and single cell spleen suspensions were stained for CD11b and CD11c. The percentages of the lymphoid-related DC (CD11blow CD11c+) and myeloid-related DC (CD11b+ CD11c+) are indicated above the gated areas.